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B cells are key elements of adaptive immunity because of their ability to produce highly specific antibodies in response to infection. Antibodies not only confer protection from pathogenic threats, but also are the basis for most currently licensed human vaccines. Despite their great importance for public health, the precise events driving the initiation of antibody production are still unknown. During the seminar, I will discuss how the spatial positioning of innate immune cells, e.g. macrophages or innate-like T cells, controls the initiation of B cell immunity during bacterial and viral infection.
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