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Conserved mechanisms amidst diversity in segmented negative-strand RNA virus polymerases
Stephen Cusack, born in London, studied mathematics, physics and theoretical physics as an undergraduate at Cambridge University and obtained a PhD in theoretical solid-state physics at Imperial College, London in 1976. Switching to molecular biology, in 1977 he joined the newly founded laboratory of EMBL at Grenoble as a postdoc to study virus structure using neutron scattering. In 1985, he spent a year learning X-ray crystallography with Don Wiley at Harvard, working on influenza virus hemagglutinin. In 1989, he became Head of EMBL Grenoble, a post he occupied until 2022. Benefitting from the establishment of the ESRF on the Grenoble Campus in the 1990s, he has focussed on using X-ray crystallography, and more recently cryo-electron microscopy, to study protein-RNA systems in gene expression, viral replication and innate immunity. He is best known for his structural analysis of aminoacyl-tRNA synthetases, the anti-viral pattern recognition receptor RIG-I, and his pioneering structural and mechanistic studies of the influenza virus RNA-dependent RNA polymerase, for which he received the Ivano Bertini Award in 2015. Several of his projects evolved a structure-based drug development aspect in collaboration with various pharmaceutical companies and in 2009, he co-founded Savira pharmaceuticals to develop anti-influenza drugs. In 1998, he became a member of the European Molecular Biology Organization and in 2015, he was elected as a member of the Royal Society of London.
Date:
9 June 2023, 14:00
Venue:
Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details:
Lecture Theatre
Speaker:
Dr Stephen Cusack, (EMBL, Grenoble)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Melissa Wright (Sir William Dunn School of Pathology)
Organiser contact email address:
melissa.wright@path.ox.ac.uk
Host:
Prof Ervin Fodor (Sir William Dunn School of Pathology)
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melissa Wright
