Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
Professional phagocytes internalise and degrade large amounts of noxious materials. Consequently, their endocytic systems are remarkably active; macrophages take up > 20% of their volume hourly. A central question in our work is how these long-lived cells maintain function while processing diverse cargo. We focus on the endo-lysosomal system and have identified SLC12A9 as a lysosomal ion co-transporter regulating lysosomal volume and fusion–fission balance, with effects on degradative capacity, luminal pH and susceptibility to damage. Ongoing work aims to define the mechanisms that regulate this transport system and its roles in phagocyte function and lysosomal physiology.
