The Regeneron Genetics Center (RGC) uses human genetics at scale to power it’s drug discovery efforts, support existing targets and find new uses for existing drugs. We collaborate widely with health systems, universities and biobanks to create cohorts with exome sequencing, genotyping and deep phenotyping. To date the RGC has sequenced nearly 3 million samples. The talk will describe some of the genetic discoveries we have made, some of the computational tools and approaches we have developed, how we use imaging data and proteomics to support this work, and some perspectives on academia and industry as a scientist.