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"An RNA-encoded virus assembly manual: mechanisms and consequences for viral evolution and therapy"
Based on a unique combination of inter-dependent bespoke modelling and experiment we have been able to demonstrate that multiple dispersed, sequence-specific interactions between (pre)genomic RNA and capsid protein promote assembly in a number of viruses infecting different hosts. In this talk, I will introduce different manifestations of this mechanism with emphasis on the examples of Human Parechovirus, Hepatitis B virus and HIV. Using the Parechoviruses as an example, I will demonstrate that characteristic features of this mechanism are shared across a viral genus, thus paving the way for broad-spectrum anti-viral therapy. Using models of viral evolution in the context of an infection, I will assess the merits of therapy directed against such features and highlight potential advantages over current therapies targeting virally-encoded enzymes. Finally, I will show that the assembly instruction manual can be isolated and repurposed for the production of VLPs, with potential for vaccination and gene delivery applications.
Date:
18 May 2018, 11:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting rooms A & B
Speaker:
Prof Reidun Twarock (University of York)
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser:
Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Host:
Prof David Stuart (University of Oxford)
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Agata Krupa
