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Proteolysis-mediated regulation of red blood cell maturation
Biography – Arno Alpi received his PhD at the Max-Planck Institute of Biochemistry and the Ludwig-Maximilian University of Munich, followed by a Postdoctoral study at the MRC-LMB, Cambridge with Prof KJ Patel, where Arno got interested in ubiquitin-mediated cell signalling in DNA damage response and the chromosome instability syndrome, Fanconi Anaemia. He then headed labs at the MRC-PPU, University of Dundee, and the Max-Planck Institute of Biochemistry, Munich, before moving back to Scotland in spring 2024 to join the Institute of Cell Biology at the University of Edinburgh. His current research interests focus on haematopoiesis and on how the ubiquitin system, in particular the multiprotein CTLH E3 ligase, modulates metabolism and gene regulation in red blood cell development.
Recent publications –
* Gottemukkala KV, Chrustowicz J, Sherpa D, Sepic S, Vu DT, Karayel Ö, Papadopoulou EC, Gross A, Schorpp K, von Gronau S, Hadian K, Murray PJ, Mann M, Schulman BA, Alpi AF (2024) “Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism” Mol Cell. 2024 May 16;84(10):1948-1963.e11.doi:10.1016/j.molcel.2024.04.014.
* Sherpa D, Müller J, Karayel Ö, Chrustowicz J, Xu P, Yao Y, Gottemukkala KV, Baumann C, Gross A,Czarnezki O, Zhang W, Gu J, Nilvebrant J, Weiss MJ, Sidhu SS, Murray PJ, Mann M, Schulman BA, Alpi AF (2022) “Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation” eLife 2022;11:e77937
* Karayel O, Xu P, Bludau I, Bhoopalan SV, Yao Y, Freitas Colaco AR, Delgado AS, Schulman BA#, Alpi AF#, Weiss MJ#, Mann M#. (2020) “Integrative proteomics reveals principles of dynamic phospho-signaling networks in human erythropoiesis” (#Co-corresponding authorship). Mol Syst Biol. (EMBO Press) 16(12):e9813. doi: 10.15252/msb.20209813.
Date:
2 September 2025, 13:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar Room
Speaker:
Dr Arno Alpi (University of Edinburgh)
Organising department:
MRC Molecular Haematology Unit
Organisers:
Kay Levendale (University of Oxford, MRC Weatherall Institute of Molecular Medicine),
Beatriz Hirt-Font (University of Oxford, MRC Weatherall Institute of Molecular Medicine)
Organiser contact email address:
mhu-pa@imm.ox.ac.uk
Host:
Prof Ketan Patel (University of Oxford)
Part of:
Molecular Haematology Unit, WIMM
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Beatriz Hirt-Font,
Kay Levendale
