New Perspectives on Innate Lymphoid Cell Development and Function
Innate lymphoid cells (ILCs) and related natural killer (NK) cells have garnered considerable interest due to their roles in immune defense and tissue homeostasis. Our current understanding of how these cells function in immune responses has been greatly facilitated by our extensive knowledge of T cell biology. Established models of T cell differentiation have provided the conceptual basis for a classification of ILCs and NK cells as innate homologues of adaptive T helper cells and cytotoxic T cells, respectively. Furthermore, activation of mature NK cells and ILCs finds parallels with known regulatory mechanisms operating within the T cell system. I will extend this ‘T cell perspective’ to discuss the developmental pathways that generate functionally distinct ILC subsets in the context of local tissue environments.
Date: 31 January 2020, 14:00 (Friday, 2nd week, Hilary 2020)
Venue: Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details: Lecture Theatre
Speaker: Professor James Di Santo (Institut Pasteur, France)
Organising department: Sir William Dunn School of Pathology
Organiser: Dawn Gibbons (Sir William Dunn School of Pathology )
Organiser contact email address:
Host: Professor Oreste Acuto (Sir William Dunn School of Pathology)
Part of: Dunn School of Pathology Departmental Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Dawn Gibbons