Macrophage contribution to Insulin Resistance independently of Inflammation
Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the multiple phenotypes and functions of macrophages in metabolic tissues. The lack of methods to carefully investigate cell-to-cell variability in macrophage phenotype and to manipulate gene expression in a cell-specific manner has delayed answering these crucial questions. Our lab takes advantage of sophisticated methods, such as next generation sequencing, CytOF and gene silencing in a cell specific manner, to investigate macrophage subpopulations and their function in obesity-associated metabolic complications.
Date: 16 November 2018, 13:00 (Friday, 6th week, Michaelmas 2018)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Large Lecture Theatre
Speaker: Dr Myriam Aouadi (Karolinska University)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Host: Professor Ana Domingos (University of Oxford, DPAG)
Part of: DPAG Head of Department Seminar Series
Booking required?: Not required
Audience: Members of the University only
Editor: Isabella Renehan