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Evolution of the Cancer Genome
In recent years there has been an explosion in both the amount of next-generation sequencing performed on cancers and in the number of computational methods used to analyse the generated data. Focusing on cancer evolution and heterogeneity, I describe the findings of my research through both large-scale projects such as the International Cancer Genome Consortium and smaller-scale studies of individual tumour types, including prostate, oesophageal, colorectal, breast and haematological cancers. These findings cover a range of topics, including: progression from benign neoplasms to cancer; mechanisms of metastatic spread; changes in mutational processes during cancer progression; variable subclonal response to treatment; the importance of the order of acquisition of driver mutations.
Date:
22 June 2017, 11:00
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
TDI, Basement meeting room, NDM Research Building
Speaker:
Dr David Wedge (Big Data Institute)
Organising department:
Ludwig Institute for Cancer Research, Oxford Branch
Organiser:
Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine)
Organiser contact email address:
mary.muers@ludwig.ox.ac.uk
Host:
Dr Gareth Bond (Ludwig Cancer Research, University of Oxford)
Part of:
Ludwig Institute Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Mary Muers,
Christina Woodward
