Spatiotemporal regulation of adaptive immunity during steady state and in response to infection with influenza virus
Adaptive immune responses are essential for the control of acute infections and for the immunity achieved following prior exposure or vaccination. This process requires that extremely rare antigen-specific B and T cells encounter their cognate antigen, receive context-specific instructive signals from innate cells, establish cognate interactions with each other, and ultimately differentiate in a controlled manner before migrating onwards to their effector sites. While seemingly unlikely, this all occurs with remarkable efficiency largely thanks to a highly evolved guidance system which directs movement of cells in particular differentiation states to specialized niches. In this talk, I will focus on our efforts to understand how this guidance system works in vivo to regulate adaptive immune cell homeostasis and activation in the context of recall responses to influenza infection.
Date:
14 March 2023, 9:30
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Room A&B
Speaker:
Dr Tal Arnon (Kennedy Institute of Rheumatology)
Organising department:
CAMS Oxford Institute
Organiser contact email address:
coi.admin@ndm.ox.ac.uk
Hosts:
Prof Tao Dong (CAMS Oxford Institute, University of Oxford),
Dr Ricardo Fernandes (CAMS Oxford Institute, University of Oxford)
Part of:
CAMS Oxford Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Natalie Baker
