In vivo functions and targets of the hub protein DYNLL1

Synopsis: DYNLL1 is a sequence-specific chaperone that promotes the ordered homo-oligomerization of more than a hundred target proteins. To define the physiologically relevant targets and mechanisms involved in its in vivo functions, my laboratory has generated a range of germline and conditional Dynll1 KO mouse models. In this talk, I will provide an overview of the roles DYNLL1 plays in normal development as well as in the onset of cancer, with particular emphasis on its function in B cells, including unpublished data on its importance as a signal-specific regulator of NF-kB signaling and antibody responses in vivo.