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The Epigenome of brain cell types and associations with disease
Dr Alexi Nott is a Lecturer in the Department of Brain Sciences at Imperial College London and a Group Leader in the UK Dementia Research Institute. His group utilizes nuclei isolation methods and genome-wide sequencing approaches to profile the epigenome of brain cell types using patient-derived archived tissue. Functional interrogation of disease-associated gene regulatory regions is explored using CRISPR DNA-editing technology of pluripotent stem cells derived into brain cell types. Using a combination of these approaches, Alexi’s research examines how genetic risk contributes to age-related brain disorders.
Date:
3 March 2025, 12:00
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
This seminar will be held in the Dorothy Crowfoot Hodgkin Building, Phase 1 Ground Floor Seminar Room (20-026). Email: opdc.administrator@dpag.ox.ac.uk for more details.
Speaker:
Dr Alexi Nott (UK Dementia Research Institute, London)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Lorraine Dyson (University of Oxford)
Host:
Professor Richard Wade-Martins (Professor of Molecular Neuroscience, University of Oxford)
Part of:
OPDC Seminar Series (DPAG)
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Lorraine Dyson
