The Sellgren laboratory uses models of the developing human brain (based on induced pluripotent stem cells) to study mechanisms that guide neurodevelopment and that are involved in different neurodevelopmental disorders (using genetic and environmental risk models). For this, skin biopsies are collected from patients at the psychiatric clinics in Stockholm and integrate experimental data with observational data obtained through genetic analyses, brain imaging, and analyses of cerebrospinal fluid. The clinical unit foremost works within the Karolinska Schizophrenia Project but also in collaboration with other cohort studies. The group have a special interest in glial modulation of developing neuronal circuits and have developed brain organoid models that incorporates both microglia and oligodendrocyte lineage cells. Combined with different functional assays, single cell multiomics techniques are also commonly used in the laboratory to characterize brain organoids.