Yi Feng’s group uses a combination of live imaging and genetic analysis in zebrafish larvae to study the earliest events of tumour initiation and progression, in vivo and in real time. They focus on the interactions between transformed cells, normal host tissue and infiltrating innate immune cells. Their research is aimed at understanding the underlying cellular and molecular mechanisms regulating tumour initiation, and the contribution of inflammation to tumour promotion with the aim of identifying fundamental mechanisms, which will underpin novel therapeutic approaches.