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Role and Regulation of DNA modifications
Several decades after the first observation of DNA modifications in mammals, we still do not know why some DNA bases are modified and whether it really matters to begin with. Although there are only three DNA methyltransferases (DNMTs) and three DNA oxygenases (TETs), an infinite number of DNA modification patterns can be observed throughout development and disease. Over the past decades, several functional links with other epigenetic pathways and cellular metabolism have been described. In this talk, I will focus on the surprising and opposing roles of TET, UHRF1 and DPPA3 in the regulation of DNA modifications and pluripotency. I will present data on the pivotal role of ubiquitination in regulating DNA modifications, as well as new regulatory mechanisms.
Date:
12 January 2026, 13:00
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
Seminar Room 2 (Room 20-138)
Speaker:
Professor Heinrich Leonhardt (Ludwig Maximilian University Munich)
Organising department:
Department of Biochemistry
Organiser:
Dr. Lothar Schermelleh (Dept of Biochemistry, University of Oxford)
Organiser contact email address:
events@bioch.ox.ac.uk
Host:
Dr. Lothar Schermelleh (Dept of Biochemistry, University of Oxford)
Part of:
Biochemistry Department Seminar
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Sarah-Jane Scard,
Jessica Barnes
