I will discuss our recent frindings on the ontogeny of secretory IgM responses, which emerge from gut plasma cells clonally affiliated to IgM+ memory B cells and some IgA+ memory B cells. I will also discuss new evidence on the biology of human IgA2 and IgD, two largely neglected mucosal antibodies. Differences between humans and mice will be emphasized.
Dr. Cerutti earned his MD in 1990 and specialized in Hematology in 1997 at Padua School of Medicine (Padua, Italy). He joined Weill Medical College of Cornell University (New York, NY) in 1996 as a Postdoctoral Fellow to do research in immunology. After finishing his post-doctoral studies, he climbed the academic ladder at Weill Medical College of Cornell University and was promoted to Assistant Professor in 2001 and Associate Professor in 2006. In 2009 he obtained Tenure and moved to Icahn School of Medicine at Mount Sinai (New York, NY) as a Professor. He also took an ICREA Professor position in IMIM (Barcelona, Spain). He published some 130 articles. The major focus of his research relates to the biology of systemic and mucosal B cells, including the regulation of antibody class switching and production. He serves as a reviewer for ERC, NIH, and other national agencies as well as all of the major immunology/biomedicine journals.