DNA end resection: from basic mechanisms to genome editing.

Petr Cejka received his Master’s degree in 2000 from the Charles University in Prague and PhD in 2004 from the University of Zurich.

The research in Prof. Cejka’s laboratory is focused on understanding how cells repair broken DNA, with a focus on a pathway termed homologous recombination. For his scientific achievements, Prof. Cejka received the Dr. Ernst Th. Jucker Award 2015 for contributions to cancer research and in 2017 the Friedrich Miescher Award from the LS2 section of Molecular and Cellular Biosciences. Prof. Cejka received an ERC (European Research Council) consolidator grant (2016) and an ERC advanced grant (2021). Recently, Prof. Cejka has been appointed a member of the European Molecular Biology Organization (EMBO).

My laboratory is using biochemical methods to study how nucleases process DNA breaks for homologous recombination. I will give an overview of the resection machineries (short- and long-range) and underlying mechanisms from human and yeast cells. I will then focus on our recent (unpublished) work that shows how the MRE11 complex recognizes DNA breaks, and demonstrate how it is relevant for genome editing. In the second part of the talk, I will cover our data on the function of CtIP in long-range DNA end resection together with DNA2.

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