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Cryo-EM structures illuminate binding sites and gating mechanisms in the pancreatic Katp channel.
Abstract: The pancreatic ATP-sensitive K+ channel (Katp) is a key regulator of insulin secretion due to its ability to couple the membrane potential to changes in intracellular glucose metabolism and is the receptor for the widely-used anti-diabetic sulfonylurea drugs. Greg, a PhD student with Prof. Show-Ling Shyng in Portland Oregon, has been using recent advances in cryo-EM to reveal near-atomic details of channel gating and regulation by sulfonylureas, while also confirming many of the in-depth functional experiments conducted over the last three decades.
Date:
15 March 2018, 14:00
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
TDI seminar room
Speaker:
Gregory Martin (Oregon Health & Science University Portland (OR), USA)
Organising department:
Structural Genomics Consortium
Organiser:
Natsumi Astley (University of Oxford )
Organiser contact email address:
natsumi.astley@sgc.ox.ac.uk
Host:
Dr Katharina Duerr (SGC Oxford)
Part of:
CMD Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Natsumi Astley
