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Understanding dysregulation of antibody and immune memory responses to chronic viral infection
in person only
Memory B-cells and antibody are key providers of long-lived immunity against
infectious disease. How chronic viral infection disrupts memory B-cells and antibody,
and whether such changes are reversible through therapeutic intervention, remains
unknown. Epigenetic programs establish the identity and function of B-cell subsets.
We therefore set out to determine how antibody responses and memory B-cells are
epigenetically altered by inflammatory signals during chronic viral infection, using
single-cell resolution of the transcriptome and chromatin landscape. Using this
system, our study revealed that type-I interferon (IFN-I) dynamics are a key
determinant in shaping chronic memory B-cell development in vivo. We further
identified the histone modifier BMI-1 as a key target to correct dysregulated antibody
responses during chronic viral infection and autoimmunity. Collectively, our research
identifies key mechanisms to instruct antibody and memory B-cell identity during viral
infection, thus laying the foundation for improving therapeutic interventions in chronic
infectious disease.
Date:
25 September 2024, 13:30
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar Room
Speaker:
Professor Kim Good-Jacobson (Department of Biochemistry and Molecular Biology, Monash University, Australia)
Organising department:
MRC Human Immunology Unit
Organiser:
Renata Sojka (MRC Translational Immune Discovery Unit, University of Oxford)
Organiser contact email address:
renata.sojka@rdm.ox.ac.uk
Part of:
MRC TIDU Wednesday Seminar Series
Booking required?:
Not required
Booking email:
renata.sojka@rdm.ox.ac.uk
Audience:
Members of the University only
Editor:
Renata Sojka
