What happens to neuronal circuits in Alzheimer’s Disease?
Alzheimer’s disease (AD) is a fatal brain disease with a massive societal impact. Identifying effective treatments for Alzheimer’s disease (AD) has proven extremely challenging and has instigated a recent shift in AD research focus towards the earliest disease-initiating cellular processes. A key insight has been that of an increase in soluble amyloid-beta in early AD that is causally linked to neuronal and circuit hyperexcitability. However, other peptides that accumulate in the AD brain, including tau, exhibit complex opposing effects on circuit dynamics (e.g. hypoexcitability). In this presentation, I will review the latest evidence base pertaining to hyper- and hypoexcitability in AD, and signpost potential pathways in which related neuronal dysfunction may be leveraged to guide biomarker identification and therapy in the disorder.
Date: 21 January 2020, 16:00 (Tuesday, 1st week, Hilary 2020)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Sherrington Room (second floor)
Speaker: Dr Marc Busche (UCL)
Organiser: Cortex Club (University of Oxford)
Organiser contact email address: raffaele.sarnataro@cncb.ox.ac.uk
Host: Raffaele Sarnataro
Part of: Cortex Club - Oxford Neuroscience Society
Topics: Alzheimer's disease, Neurosciences
Booking required?: Not required
Audience: Public
Editors: Raffaele Sarnataro, Marta Blanco pozo, Ilenia Salaris