CD4 T cells Sans Frontières
In-person only
Understanding how immune cells operate within tissues is key to designing better mucosal vaccines and therapies. In this talk, I will discuss how hypoxia-inducible factor 1-alpha (HIF-1α) shapes CD4 T cell fate within lung tertiary lymphoid structures during influenza infection. Using spatial transcriptomics and inducible gene deletion, we uncover a distinct population of HIF-1α+ T cells that orchestrates local immunity—supporting antibody production, innate cell recruitment, and tissue homeostasis.
Date:
30 June 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Prof Carolyn King (University of Basel)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Host:
Dr Mariana Borsa (Simon Group, Kennedy Institute of Rheumatology, University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Magdalena Gross
