Developmental pathways for lymphatic endothelial cells in zebrafish
Abstract:

The vertebrate lymphatic vasculature is essential for normal tissue fluid drainage and immune cell trafficking. Insufficient lymphatic development can lead to lymphoedema, while on the flip side excessive lymphangiogenesis contributes to the spread of cancer and is central in the aetilogy of a number of vascular pathologies. To understand fundamental molecular mechanisms common in development and disease we have used complementary large scale forward genetic screens and targeted reverse genetic screening approaches. Recently, we have uncovered unexpected roles for pre-mRNA splicing and its regulation by Nova2 in both zebrafish and mouse. We have also characterised unexpected new targets of the Hippo signalling pathway and its transcriptional effector Yap1 that are essential to drive lymphangiogenesis. In this talk, we will explore these new and unexpected mechanisms of lymphangiogenesis as well as sharing several early unpublished observations.
Date: 11 August 2023, 15:00
Venue: IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details: IDRM Seminar Rooms
Speaker: Dr Ben Hogan (Peter MacCallum Cancer Centre)
Organisers: Dr Thomas Roberts (Department of Paediatrics), Dr Rebecca Berrens (Department of Paediatrics), Dr Filipa Simões (DPAG, IDRM, University of Oxford), Associate Professor Carlo Rinaldi (University of Oxford, MDUK Oxford Neuromuscular Centre), Dr Oliver Stone (University of Oxford, Department of Physiology, Anatomy and Genetics (DPAG))
Part of: IDRM Seminar Series
Booking required?: Required
Booking email: rufina.kaloyanova@paediatrics.ox.ac.uk
Audience: Members of the University only
Editor: Rufina Kaloyanova