The role of 5-hydroxymethylcytosine in liver metastasis in colon cancer

Adele Murrell investigates a wide range questions in epigenetics, with a particular focus on cancer. Her work includes analysis of epigenetic reprogramming during metastases. When cells metastasise from a primary cancer site to a new site, they undergo epigenetic reprogramming events that enable them to migrate, infiltrate, adapt and colonise a new environment. A future goal of her work is to identify the triggers of these epigenetic changes with a view to prevent secondary tumour formation in cancer.