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A mitochondria-lipid droplet stress pathway drives metabolic flexibility and cell survival
Mitochondria undergo stress induced hyperfusion to adapt their metabolic function and safeguard cellular survival during starvation.
The mechanisms that regulate the underlying cell-biological program are however largely unknown.
In this talk I am going to discuss how lipid transfer at contact sites between mitochondria and lipid droplets controls metabolic remodelling and promotes cell survival.
Specifically I will explain how the lipid transfer protein mitoguardin 2 couples these fundamental aspects of cell physiology.
Date:
14 November 2025, 13:00
Venue:
Sherrington Library, off Parks Road OX1 3PT
Venue Details:
Sherrington Building
Speaker:
Associate Professor Robin Klemm (DPAG, University of Oxford)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organisers:
Dr Thomas Keeley (DPAG, University of Oxford),
Dr Mootaz Salman (DPAG, University of Oxford)
Organiser contact email address:
events@dpag.ox.ac.uk
Host:
Dr Tom Keeley (DPAG, University of Oxford)
Part of:
DPAG Head of Department Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Hannah Simm
