OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Understanding how immune cells operate within tissues is key to designing better mucosal vaccines and therapies. In this talk, I will discuss how hypoxia-inducible factor 1-alpha (HIF-1α) shapes CD4 T cell fate within lung tertiary lymphoid structures during influenza infection. Using spatial transcriptomics and inducible gene deletion, we uncover a distinct population of HIF-1α+ T cells that orchestrates local immunity—supporting antibody production, innate cell recruitment, and tissue homeostasis.
