POSTPONED Heart Growth and Regeneration: Crossing the Line
Status: This talk is in preparation - details may change
It is generally thought that the adult heart has too little endogenous ability to appreciably restore myocardium that is lost after ischemia or infarction. In contrast, the fetal and early neonatal heart have a very high capacity for cardiomyocyte proliferation and regeneration. Why and how the mammalian heart becomes essentially nonregenerative is one of the enduring mysteries of heart biology. Using genetic approaches, my lab has redefined natural heart regeneration as a variable trait subject to the combined influences of multiple polymorphic genes. With this perspective, a number of longstanding questions now become amenable to experimental evaluation. In this presentation, I will discuss genetic, cellular, and mechanistic insights that have been realized based on this new paradigm, and potential therapeutic strategies that could improve endogenous heart regeneration in all patients regardless of their genetic and cellular composition.
Date: 23 April 2020, 12:00 (Thursday, 0th week, Trinity 2020)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Small Lecture Theatre, Second Floor
Speaker: Professor Henry M. Sucov, PhD (Department of Regenerative Medicine and Cell Biology, Division of Cardiology, Department of Medicine, Medical University of South Carolina)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Professor Paul Riley (DPAG, University of Oxford)
Organiser contact email address:
Host: Professor Paul Riley (DPAG, University of Oxford)
Part of: Development & Cell Biology Theme Guest Speakers (DPAG)
Booking required?: Not required
Audience: Members of the University only
Editor: Talitha Smith