OxTalks is Changing
During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
Reverse Engineering the Brain: From Stem Cells to Neurons to Circuits in a Dish
With the rise of human pluripotent stem cells and ever-improving differentiation protocols, we now have a powerful tool to explore human-specific aspects of brain development and function. In this talk, I will first give an overview about how we differentiate stem cells into 3D tissues (commonly known as neural organoids) that mimic human brain development and function. I will then share two examples of our recent work, in which we recapitulate brain region interactions. First, I will discuss how we have modelled interneuron migration by fusing organoids that represent distinct brain regions. Then, I will present work in which we re-grew the human dopaminergic system using a ventral midbrain : striatal : cortical differentiation strategy and spatially assisted fusion. Finally, I will discuss ongoing research in the Stevens Group and how we think these technologies, together with the enormous capabilities of bioengineering, can shape the future: from a fundamental understanding of human brain development to function, disease modelling and translational trajectories.
Date:
17 February 2025, 16:00
Venue:
Sherrington Library, off Parks Road OX1 3PT
Venue Details:
In the Sherrington Building, DPAG
Speaker:
Dr Daniel Reumann (University of Oxford)
Organising department:
MRC Brain Network Dynamics Unit
Organiser:
Sasha Tinelli (University of Oxford)
Organiser contact email address:
sasha.tinelli@chch.ox.ac.uk
Host:
Sasha Tinelli (University of Oxford)
Booking required?:
Not required
Audience:
Public
Editor:
Sasha Tinelli
