The Global Research on AntiMicrobial resistance (GRAM) project aims to provide robust, comprehensive and timely evidence of the burden of antimicrobial resistance (AMR) globally, and in 195 countries and territories. This work is being run within a partnership between the University of Oxford and the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. The overall aim of the GRAM initiative is to strengthen the evidence base on the current global burden of AMR, and how, where and why it is changing. We will provide the essential health intelligence to help drive awareness of AMR, support better surveillance of AMR, and prompt policy action to control AMR, including facilitating antimicrobial stewardship. In this talk I will describe our objectives on consolidating, reviewing and analysing the available data and scientific information on AMR worldwide, in order to generate comparable AMR burden estimates for all clinical syndromes and pathogen-drug combinations, and our approach to producing the burden of disease maps together with some of the difficulties encountered.