OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Summary of Research
The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. To achieve this goal we rigorously investigate the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) using both physiologically relevant as well as pathological inflammatory models. A key component of our work is a research programme that investigates how pathological inflammatory insults impact the dynamics of neutrophil-vessel wall interactions and the implications of disrupted modes of neutrophil transmigration (eg neutrophil reverse transmigration) on inflammatory disease development and dissemination. Collectively through the application of advanced imaging platforms such as confocal intravital microscopy to analyse leukocyte-vessel wall interactions in vivo, our work aims to unravel previously unexplored cellular and molecular physiological concepts and identify disease-specific phenomena.
Our work is largely funded by the Wellcome Trust (Senior Investigator Award) and several grants from the British Heart Foundation and the Arthritis Research UK.
