Disease genes and 'healthy' human gene knockouts: Genetics for therapeutic innovation?

Professor Richard C Trembath is the Vice Principal ‚ Health Queen Mary University of London and the Head of the Barts and the London School of Medicine and Dentistry. Prior to joining Queen Mary, Professor Trembath was the Director of the NIHR Comprehensive Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and Head of the KCL Division of Genetics & Molecular Medicine at King’s College London. He is Honorary Consultant in Clinical Genetics, a recent Senior Investigator of the National Institute of Health Research, a Fellow of the Academy of Medical Sciences, a non-Executive Director of Barts Health NHS Trust and sits on the Academic Health Sciences Board of the UCL Partnership. Professor Trembath’s research interest has led to the identification of disease genes and the delineation of molecular pathways underlying a range of rare human genetic disorders, including familial pulmonary arterial hypertension. Working with Jonathan Barker he has contributed to the present understanding of the genetic architecture of a range of common inflammatory skin conditions. Most recently, together with David Van Heel and Richard Durbin, he has developed a large scale population based genomic initiative, East London Genes and Health, an ambitious programme to support precision medicine.