Novel system-wide methods to study protein-RNA interactions in infection and cell-fate decisions

The main goal of the Castello lab is to elucidate the role that RNA-binding proteins (RBPs) play in cell-fate decisions and infection with human viruses. They aim to determine the repertoire of RBPs involved in virus infection and cell-cycle progression by applying the state-of-the-art proteomics and RNA sequencing. Identified cell-fate regulators are further characterized using molecular and cellular biology methods as well as animal models. Through understanding the biological role of these RBPs, they hope to uncover unexplored aspects of cell division and infection.