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Tracking Jak-STAT signalling in inflammatory arthritis
This seminar will be held using Zoom. Please join here: https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA) are highly context dependent. Rheumatoid arthritis patients often display very different patterns of local synovial pathology– termed fibroblast-rich, myeloid-rich and lymphoid-rich synovitis. My overarching goal is to identify the decision-making processes affecting the clinical presentation of these synovial pathotypes. Combining functional genomic approaches and histological studies in mice and humans I will discuss how cells within the inflamed synovium sense and interpret cytokine cues linked with these pathotypes. With a primary focus on cytokines that signal through the latent transcription factors STAT1 and STAT3, I will provide new insights into the potential role of protein tyrosine phosphatases as biological rheostats of Jak STAT signalling within the inflamed joint.
Date:
21 September 2020, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held using Zoom. Please join here: https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Speaker:
Prof Simon Jones (Cardiff University)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://zoom.us/meeting/register/tJwrdeuvpz0uHNOzE5-OMiSw1_1BfZ3oFReZ
Audience:
Public
Editor:
Jennifer Pope
