Functional dynamics of chromatin topology in human cardiogenesis and disease

Please contact Katie McNeil if you would like to meet with Alessandro during his visit

Dr. Alessandro Bertero is a Senior Fellow in the Dept. of Pathology at the University of Washington in Seattle, USA. During his undergraduate studies he trained with the late Prof. Guido Tarone at the University of Turin in Italy, where he contributed to elucidate the Melusin-ERK1/2 signalling pathway in cardiac hypertrophy, and obtained a BSci (2009) and an MSci (2011). Having being awarded a British Heart Foundation Graduate Fellowship, he joined the laboratory of Prof. Ludovic Vallier at the University of Cambridge in the UK, where he obtained an MRes (2012) and a PhD (2016) by revealing the epigenetic and epitransciptional effects of TGFbeta-SMAD2/3 signalling during early differentiation of human pluripotent stem cells (hPSCs). In 2016, Dr. Bertero moved to the University of Washington for his postdoctoral training with Prof. Charles Murry. He was awarded an EMBO Long-Term Fellowship in 2017. His current focus is the study of three-dimensional chromatin organization, and of its importance both during human cardiogenesis and in the context of familiar cardiomyopathies. This work relies on stage-wise differentiation of hPSCs into cardiomyocytes, CRISPR/Cas9 gene editing, generation of 3D engineered heart tissues, analysis of cardiac physiology, and genomic approaches to probe nuclear architecture and function.