The UK Clinical Vaccine Network Conference 2019 is a single day conference focusing on the future direction and challenges within the vaccine arena. The aim of the conference is to showcase the work of the UK clinical vaccine community and will be open to anyone who wants to learn more about vaccines. Topics covered will range from correlates of protection, adjuvants, novel delivery and AMR, through to global vaccines and vaccine acceptance. As part of the event there will be a masterclass session for trainees and will have a plenary speaker talking about careers in vaccinology. The conference will cover recent vaccine development in RSV, typhoid, rabies, CMV, and the potential impact of vaccines on antimicrobial resistance, as well as discussion around vaccine uptake and hesitancy. The programme is targeted towards clinical and non-clinical staff alike.