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Environment control of T cell function
Delivered via Zoom
The T lymphocyte response to pathogens is shaped by the T cell microenvironment and key
environmental signals are provided by amino acids, glucose and oxygen. Environmental
sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine
monophosphate-activated protein kinase and mammalian target of rapamycin complex 1 and
signaling pathways regulated by intracellular protein O-GlcNAcylation. Other environmental
sensors are transcription factors such as c-myc and hypoxia-inducible factor-1 alpha.The
present talk will explore the molecular basis for the impact of environmental signals on the
differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune
stimuli can coordinate the T cell response to environmental cues.
Date:
15 May 2020, 14:00
Venue:
Via Zoom
Speaker:
Professor Doreen Cantrell (Professor of Cell Biology and Immunology and Wellcome Trust Principal Research Fellow, University of Dundee)
Organising department:
Sir William Dunn School of Pathology
Organiser:
Dawn Gibbons (Sir William Dunn School of Pathology )
Organiser contact email address:
dawn.gibbons@path.ox.ac.uk
Hosts:
Dr Marion H Brown (Sir William Dunn School of Pathology, Oxford),
Dr Omer Dushek (Sir William Dunn School of Pathology, Oxford)
Part of:
Dunn School of Pathology Departmental Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Dawn Gibbons
