Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
T cell responses upon infection display a remarkably reproducible pattern of expansion, contraction and memory formation. It is unclear, whether the robustness of this pattern builds entirely on signals derived from other cell types, or whether activated T cells themselves contribute to the orchestration of these population dynamics – akin to bacterial quorum-regulation. We examined this question and found that cell clustering enabled CD8+ T cells to collectively regulate the balance between proliferation and apoptosis. Mechanistically, this was mediated by two nested antagonistic feedback circuits, whose competition was modulated by T cell density. Such population-intrinsic regulation of cellular behavior promotes robustness of population dynamics.
