On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
T cell responses upon infection display a remarkably reproducible pattern of expansion, contraction and memory formation. It is unclear, whether the robustness of this pattern builds entirely on signals derived from other cell types, or whether activated T cells themselves contribute to the orchestration of these population dynamics – akin to bacterial quorum-regulation. We examined this question and found that cell clustering enabled CD8+ T cells to collectively regulate the balance between proliferation and apoptosis. Mechanistically, this was mediated by two nested antagonistic feedback circuits, whose competition was modulated by T cell density. Such population-intrinsic regulation of cellular behavior promotes robustness of population dynamics.
