Molecular archaeology of cancer
Cancer evolves dynamically as clonal expansions supersede one another, driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer’s life history is encrypted in the somatic mutations present. We are developing algorithms to decipher this narrative from whole genome sequencing data and are applying them to several cancer types. We call such approaches molecular archaeology of cancer, as we are using genomics and bioinformatics algorithms to infer a tumour’s evolutionary history. I will discuss applications of our methods to breast cancer, allowing us to disentangle subclonal architecture from whole genome sequencing data, as well as time events such as chromosome duplications along a tumour’s lifetime. In addition, I will describe how extending these molecular archaeology approaches to multiple sampling studies allow enhanced and unique insights into cancer evolution, and I will illustrate that using genomics studies on prostate cancer metastases, where we are able to elucidate the patterns of metastatic spread in unprecedented detail.
Date:
19 March 2015, 14:00 (Thursday, 9th week, Hilary 2015)
Venue:
Old Road Campus Research Building, Headington OX3 7DQ
Venue Details:
Room 71abc, Ground floor
Speaker:
Peter Van Loo (LRI/Crick Institute)
Organising department:
Department of Oncology
Organisers:
Anastasia Samsonova (University of Oxford),
Christopher Yau (University of Oxford)
Organiser contact email address:
cyau@well.ox.ac.uk
Host:
Christopher Yau (University of Oxford)
Part of:
Cancer Bioinformatics Seminar Series
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Christopher Yau
