Secrets of heart regeneration revealed by comparative analyses in regenerative vs. non-regenerative models
Secrets of heart regeneration revealed by comparative analyses in regenerative vs. non-regenerative models

Our laboratory performs comparative analyses in animals capable or incapable of heart regeneration to understand the cellular and molecular bases of this process. Particularly, zebrafish display a distinct ability to regenerate their heart following injury. However, this ability is not shared by another teleost, the medaka. Transcriptomic profiling revealed major differences in immune cell dynamics and gene expression between these models after cardiac injury. Functional experiments further showed that macrophage heterogeneity and functions are essential for zebrafish heart regeneration, while modulating immune response may enhance immune cell function and promote neovascularization, neutrophil clearance, cardiomyocyte proliferation, and scar resolution in medaka. Altogether, our research gains insights into the complex role of the immune response during heart regeneration and serves as a platform to identify and test novel regulators for therapeutic development.
Date: 1 September 2023, 15:00 (Friday, 19th week, Trinity 2023)
Venue: IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details: IDRM Seminar Rooms 1&2
Speakers: Speaker to be announced
Organisers: Dr Thomas Roberts (Department of Paediatrics), Dr Rebecca Berrens (Department of Paediatrics), Dr Filipa Simões (DPAG, IDRM, University of Oxford), Associate Professor Carlo Rinaldi (University of Oxford, MDUK Oxford Neuromuscular Centre), Dr Oliver Stone (University of Oxford, Department of Physiology, Anatomy and Genetics (DPAG))
Organiser contact email address: rufina.kaloyanova@paediatrics.ox.ac.uk
Host: Dr Oliver Stone (University of Oxford, Department of Physiology, Anatomy and Genetics (DPAG))
Part of: IDRM Seminar Series
Booking required?: Required
Booking email: rufina.kaloyanova@paediatrics.ox.ac.uk
Audience: Members of the University only
Editor: Rufina Kaloyanova