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Axes of T cell diversification
In person
When naïve T cells are activated and clonally expand, the progeny differentiates into functionally distinct states or ‘subsets’. The differentiation state of a T cells is indicative of its functional and migratory properties, and T cell differentiation states are linked to clinical outcome, for example, after infection, adoptive T cell therapy or transplantation. It has, however, been difficult to translate T cell behavior across species. I will be presenting a practical strategy to facilitate two-way crosstalk between human and mouse settings, and propose a new conceptual framework to study T cell diversification.
Date:
4 November 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Lecture Theatre
Speaker:
Dr Carmen Gerlach (the Karolinska Institute, Stockholm)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Dr Audrey Gerard (The Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
