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From immune regulation to anti-tumor effects: A tale of cytotoxic regulatory T cells
In person
Achieving a graft-versus-leukemia (GVL) effect while suppressing graft versus host disease (GVHD) is the ultimate goal for allogeneic hematopoietic cell transplantation. Circulating CD8 regulatory T cells (Treg) that are capable of immunosuppression and cytolysis are rare. Therefore, we developed a protocol to generate human CD8 induced Tregs that are expansile and possess dual CD8 CTL cytotoxicity, consistent with their cell surface and intracellular expression patterns. When transduced with a chimeric antigen receptor, CD8 iTregs and cytotoxic T cells are equally cytolytic against their targets in vitro and in vivo, reflecting their dual function. Mechanism(s) underlying these properties will be discussed.
Date:
4 October 2024, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Prof Bruce Blazar (University of Minnesota)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address:
doris.chan@kennedy.ox.ac.uk
Host:
Michael Dustin (Kennedy Institute, University of Oxford)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Doris Chan
