Progression from latent M. tuberculosis infection to TB disease
Up to one-third of the global population is thought to harbour M. tuberculosis infection, but only a fraction of infected persons progress to active TB disease. It is unclear why only some infected individuals progress to TB disease, while others do not. Using systems immunology we dissected the immunobiology underlying progression from M. tuberculosis infection to active disease in a longitudinal study, and developed transcriptomic and proteomic correlates of TB risk that identify progressors before diagnosis of TB disease is possible. Predicting disease progression in asymptomatic individuals provides an opportunity for chemotherapeutic intervention and potential prevention of M. tuberculosis transmission.
Date:
31 October 2016, 12:00 (Monday, 4th week, Michaelmas 2016)
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Call 281231on arrival for entry
Speaker:
Dr Thomas Scriba (University of Cape Town, South Africa)
Organising department:
Nuffield Department of Clinical Medicine
Organiser:
John Frater (University of Oxford)
Organiser contact email address:
john.frater@ndm.ox.ac.uk
Part of:
Peter Medawar Building Seminars
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Chris Willberg
