During Michaelmas Term, OxTalks will be moving to a new platform (full details are available on the Staff Gateway).
For now, continue using the current page and event submission process (freeze period dates to be advised).
If you have any questions, please contact halo@digital.ox.ac.uk
Generation of cortical neurons from endogenous progenitor cells is limited to prenatal development. In the human brain the process starts in the first trimester and the new neurons integrate in the developing neuronal networks early on. Disturbance of this early developmental process is indicated to result in neuronal network dysfunction manifesting as psychiatric conditions later in life. Studying how these processes are regulated and what cells are involved would help us understand how new cortical neurons can be generated and how the establishment of new synaptic connections can be facilitated. In my talk I am going to present our findings on the regulation of self-renewing cortical neural stem cells and the capture of a novel immune cell state involved in the establishment of active synapses between cortical neurons.