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Unlock the adaptive immune repertoire by controlling innate immunity with biomaterials
The immune system consists of two parts: innate immunity and adaptive immunity. T cells and B cells in the adaptive immune system are two major players to mount an antigen-specific defense and offer long-term protection. However, due to the immune tolerance and immunodominance mechanisms, some T cells and B cells can recognize the antigens but couldn’t develop effective immune responses.
My research focus is using synthetic biomaterials to engineer the innate immune system and unlock the non-responsive adaptive immune repertoire for new cancer immunotherapies and infectious disease vaccines. In this seminar, two examples illustrating my research work will be described. In the first example, I develop a toll-like receptor 7 agonist-based nanoparticle (TLR7-NP) adjuvant to alter germinal center (GC) signaling and induce high levels of cross-reactive antibody responses to multiple heterologous viral variants of influenza and SARS-CoV-2.
The second example is to design a nanoparticle platform to reverse the anergy of tumor infiltrating self-specific CD8+ T cells for creating a new and effective immunotherapeutic strategy for treating broad cancer patients.
Date:
19 February 2024, 14:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Room A+B
Speaker:
Dr. Qian Yin (University of Texas at Austin, United States)
Organising department:
CAMS Oxford Institute
Organisers:
Dr Ricardo Fernandes (CAMS Oxford Institute),
Dr Dannielle Wellington (CAMS Oxford Institute),
Mimie Szyk (CAMS Oxford Institute)
Part of:
CAMS Oxford Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Mimie Szyk
