Pathogenetic Mechanisms of Muscule Wasting in Disease

Previous title : Signalling pathways that control muscle mass, metabolism and longevity

Marco Sandri1,2,3
1Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy. 2 Venetian Institute of Molecular Medicine, 35129 Padova, Italy.3Myology Center, University of Padova, 35131 Padova, Italy

The ability to activate compensatory mechanisms in response to environmental stress is an important factor for survival and maintenance of cellular functions. The proteolytic pathways, which include autophagy lysosome and ubiquitin proteasome (UPS) systems, are often activated both in short and prolonged stress conditions. Autophagy is required to clear the cell from dysfunctional organelles and altered proteins but, when strongly activated, it contributes to muscle wasting. Autophagy also control mitochondrial network and cellular bioenergetics. The autophagy and UPS systems are regulated by different signaling pathways that also impinge on proteins synthesis. I’ll present the last data about regulation of protein and organelle turnover and how these systems contribute to muscle wasting, disease progression, energy production, calcium homestasis and organism survival.