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A hallmark of the adaptive immune system is its ability to generate long-lasting memory that protects against reinfections. In antibody-mediated responses, memory is maintained by plasma cells and memory B-cells (MBCs), with a diverse pool of MBCs being important for responses to new pathogen variants. Mechanisms underlying MBCs’ longevity, rapid responsiveness, and diversity remain largely unknown. This talk will focus on published and unpublished results that unravel key aspects of MBC heterogeneity and how this influences their function and maintenance.
