Host MHC and genomic diversity retards experimental evolution of viral virulence
Please arrive 5 minutes before the seminar to gain access to the building
Experimental evolution of a mouse-specific retrovirus in various host genotypes reveal increases in fitness and virulence by 50- and 20-fold respectively. The virus adapts to specific host genotypes as indicated by its’ reduced ability to infect other host genotypes, including those that differ only at histocompatibility loci. Three round serial passages where the host genotype is alternated once, dramatically reduces viral fitness and virulence. Full genome sequencing of these evolved viral lines reveal surprising results where no mutations have become fixed despite strong selection operating over 240 generations.
Date:
28 November 2018, 12:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Level 30 Seminar Room
Speaker:
Professor Wayne Potts (University of Utah)
Organising department:
Nuffield Department of Clinical Medicine
Organisers:
Professor Sunetra Gupta (University of Oxford),
Prof Lynn Dustin (NDORMS)
Organiser contact email address:
thomas.johnson@tss.ox.ac.uk
Host:
Professor Sunetra Gupta (University of Oxford)
Part of:
Peter Medawar Building Seminars
Topics:
Booking required?:
Not required
Cost:
FREE
Audience:
Members of the scientific community
Editor:
Thomas Johnson
