OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Searching for neurodevelopmental causes of schizophrenia
Whereas the exact causes of schizophrenia are unknown, abnormal neural developmental is a strong risk factor. The Szele group examine this relationship with human induced pluripotential stem cells (hIPSC), post-mortem human histology and a mouse model and find the three approaches indicate neurodevelopment is altered in schizophrenia. Our hIPSC data, generated in collaboration with Tony James and international colleagues indicate that mTOR signalling is significantly disrupted in schizophrenia. Histological examination of the caudate nucleus showed a significant decrease in calretinin+ cells in the disease. Finally, our dysbindin mutation x inflammation mouse model had disrupted neural stem cell niches.
To join virtually, please use the Zoom link below:
us06web.zoom.us/j/83345543063?pwd=djQ5SlBPVG5lZm4xazBZTU1tVjg1dz09
Date:
18 October 2022, 9:30
Venue:
Seminar Room
Speaker:
Professor Francis Szele (University of Oxford)
Organising department:
Department of Psychiatry
Organiser contact email address:
rania.elgarf@psych.ox.ac.uk
Host:
Professor Noel Buckley (University of Oxford)
Part of:
Psychiatry Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Diana Verley,
Rania Elgarf
