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Barcoding the mouse germline to the next generation
Germline is the only cell lineage transmitted to the next generation. De novo mutations occurring in these cells will be conveyed by sperm and eggs to the next generation. Therefore, the fate behaviours of a germ cell clone are critical for transmitting the mutations in their genome. However, the germline cells’ clonal dynamics remains largely unknown in mammals.
Using a DNA barcoding methodology, we are analysing the clonal lineage behaviour of the entire germ cell population in male mice – from immediately after specification in early embryos through primordial germ cell proliferation, sex determination, sperm stem cell establishment and maintenance, and spermatogenesis. We further analysed the transmission of barcoded genomes to the next generation. We found that a considerable fraction of clones get extinct during early development. While, germ cells surviving this stage maintain their clonal diversity till adulthood, proportionally transmitted to the next generations. I would discuss the potential significance and regulatory mechanisms of observed clonal dynamics.
Date:
31 January 2023, 11:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
WIMM Seminar Room
Speaker:
Prof Shosei Yoshida (National Institute for Basic Biology (NIBB), Japan)
Organising department:
MRC Weatherall Institute of Molecular Medicine
Organisers:
Karen Brown (Weatherall Institute of Molecular Medicine),
Professor Anne Goreily (University of Oxford, Weatherall Institute of Molecular Medicine)
Organiser contact email address:
seminar.admin@imm.ox.ac.uk
Host:
Professor Anne Goreily
Booking required?:
Not required
Booking email:
seminar.admin@imm.ox.ac.uk
Audience:
Members of the University only
Editor:
Karen Brown
