Uterine fibroids are benign lesions of uterine myometrial tissue causing heavy menstrual bleeding and reduced fertility. Due to limited treatment options fibroids are the primary indication for hysterectomy. My talk will discuss the role of several metabolic factors among women with fibroids. The newly published fibroid GWAS meta-analysis identifies 29 genome-wide significant loci. Interestingly several of these loci associate with CVD trait. Based on a unique MRI screening data, my research shows that fibroid incidence among Finnish women is significantly lower than what is stated previously. We suggest that Finnish women share protective factors against fibroid tumourigenesis.