Thymic development of Mucosal-Associated Invariant T (MAIT) cells
T cells play an important role in the immune system by detecting microbial molecules that signal infection. While most studies have focussed on T cells that detect foreign peptides, recent studies have shown that a major T cell population called MAIT cells recognise microbial vitamin B2 derivatives presented by the molecule, MR1. Using MR1 tetramers, we describe how MAIT cells develop in the thymus and identify key checkpoints that control the maturation of these cells.
Date: 16 June 2016, 11:00 (Thursday, 8th week, Trinity 2016)
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: WIMM Seminar room
Speaker: Dr Daniel Pellicci (Research Fellow, University of Melbourne)
Organising department: MRC Human Immunology Unit
Organiser: Anne Farmer
Organiser contact email address:
Host: Prof Vincenzo Cerundolo (MRC Human Immunology Unit, WIMM, University of Oxford)
Booking required?: Not required
Audience: Members of the University only
Editor: Renata Sojka